Environmental Bio-Detection Products Inc. (EBPI) services

Biomedical and environmental regulatory toxicology encompasses the collection, processing, and evaluation of experimental toxicology data to permit educated decisions on protecting and maintaining human and environmental health against harmful effects caused by natural and synthetic chemical substances. To make these types of decisions, a battery of assays need to be performed and professionals who are proficient in the analysis and interpretation of this data are required to sift through and find the most pertinent material.

Biomedical and environmental regulatory toxicology encompasses the collection, processing, and evaluation of experimental toxicology data to permit educated decisions on protecting and maintaining human and environmental health against harmful effects caused by natural and synthetic chemical substances. To make these types of decisions, a battery of assays need to be performed and professionals who are proficient in the analysis and interpretation of this data are required to sift through and find the most pertinent material.

The Direct Toxicity Tests utilized at EBPI Analytics offer acute, sub-chronic and chronic endpoints for a variety of bacteria, micro fauna, marine invertebrates, vertebrates and plant species. The data collected from these assays provide LC50, LOEL and NOEL concentration data for test compounds in aqueous samples (fresh and marine water) and sediment samples.

Bacterial Identification, Quantification and Characterization Assays; EBPI Analytics offers several different assays to evaluate bacterial contamination. We are very excited about our service possibilities as they can be combined with one another to provide a great deal of information about all types of bacterial contamination issues. We detect the presence and quantity of bacterial indicators which serve as markers for fecal contamination. Furthermore, EBPI Analytics and its partners at Microbial Insights, offer bacterial characterization services to identify the source of contamination and provide possible rationales for the test results. In this way, we offer a COMPLETE STORY for clients dealing with bacteria issues.

EBPI Analytics offers a large selection of traditional Ames tests to meet any research requirement. There are multiple options offered for these assays, and clients can choose from different bacterial strains, developed for specific sensitivities to mutation type. We also offer both Salmonella and E. coli test bacteria which allows standardization of our assays to previously established test protocols depending on client requirements. Clients can also choose between three assay methods including a standard plate assay, fluctuation test, and a modified ISO procedure. The assay choices promote flexibility depending on personal preference, budget, application, or experimental design. We also offer optional addition of S9 fraction rat liver extracts to metabolically bioactivate genotoxins, which increases the number of mutagenic compounds detected by the Ames assays.

In addition to the specific mutagenicity assays provided by EBPI Analytics, a line of general genotoxicity tests are offered. These assays use modified bacteria that have the induction of a SOS DNA response gene coupled to a gene that expresses a measurable colorimetric endpoint. The degree of induction of the SOS response can be quantified by the degree of colour change, and correlates with the amount of DNA damage in the cell from toxicant exposure. These assays conform to international ISO standards and were suggested for incorporation into legislation for waste water effluent testing as part of the OSPAR commission (2002). They are currently mandated in Europe as part of the water framework directive (WFD).