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Direct Toxicity Tests Services
The Direct Toxicity Tests utilized at EBPI Analytics offer acute, sub-chronic and chronic endpoints for a variety of bacteria, micro fauna, marine invertebrates, vertebrates and plant species. The data collected from these assays provide LC50, LOEL and NOEL concentration data for test compounds in aqueous samples (fresh and marine water) and sediment samples.
This data is required in many areas including:
- Primary toxicological assessments
- Drinking/waste water testing
- Pesticide approval
- Environmental remediation
- Pharmaceutical development
A number of these assays are required in international water effluent quality testing protocols including WSER, NPDES, and WFD. The direct toxicity assays run at EBPI Analytics have been used extensively in government, academia, and industry.
Most of the assays provided at EBPI Analytics follow developed standardized protocols in accordance with the ISO, OECD, and EPA. Several of the assays with no current international standard are in the approval process to be standardized.
The bioluminescence inhibition assay uses Vibrio fischeri bacteria to measure acute toxicity of complex effluents, chemcial mixtures and pure compounds. This bioassay has been standardized and is utilized in several countries. Assay bacteria are subjected to the sample mixture and bioluminescence is measured after an exposure time with a luminometer. Inhibition of bioluminence, which is controlled by several bacterial systems and can be affected by protein synthesis, metabolism or energy production, is the response indicator of toxicity. The samples are compared to negative and positive control solutions to obtain data.
Benefits to this assay are
- Standardized test method run according to ISO 11348-3
- Relatively quick turn-around time
- Cost effective
- Ideal for marine samples