ISS, Inc.

Since 1984, ISS has been committed to the development and design of highly sensitive scientific instrumentation for research, clinical and industrial applications. Over the years, our innovations introduced to research-grade fluorescence instrumentation generated a second product line for medical applications. In 1992, ISS started a project with the research group at the University of Illinois at Urbana-Champaign headed by Prof. Enrico Gratton and aimed at understanding the behavior of fluorophores in scattering and turbid media; the goal was the development of an instrument suitable for the non-invasive measurements of metabolites in the human body. As a result of this collaboration, ISS introduced a non-invasive Tissue Oximeter for the measurement of the absolute oxygen concentration in tissues, called OxiplexTS. The first prototype of the instrument was completed in 1998; about one hundred units of OxiplexTS have been installed worldwide so far.