Nanolytics GmbH services

AUC Services

Analytical Ultracentrifugation Services

Nanolytics GmbH is a renowned provider of analytical ultracentrifugation (AUC) services with over two decades of experience. Equipped with advanced centrifuges, their equipment can enhance sensitivity by a factor of five and capture full spectra for comprehensive sample characterization, employing techniques such as sedimentation velocity and density variations. This makes AUC a valuable tool in the in-depth analysis of particles and molecules concerning size, mass, and conformation. Nanolytics' expertise lies in designing tailored AUC experiments, utilizing both proprietary and leading third-party software tools for precise data analysis. Their service is especially notable in the pharmaceutical sector, where they handle complex analyses and maintain seamless collaboration with clients to optimize project outcomes. Their commitment to quick turnaround times ensures that analyses are performed swiftly and reports are provided promptly, supporting the critical timelines of pharmaceutical research and development.

Biopharmaceuticals

Analytical Services for Protein Aggregates

This company specializes in offering Analytical Ultracentrifugation (AUC), a crucial method for quantifying protein aggregates in biopharmaceuticals and biologics, including monoclonal and fragment antibodies, interleukins, and recombinant proteins. Protein aggregation poses significant risks in therapeutics due to its complex structural nature, which can result in larger aggregates that affect patient safety upon administration. AUC provides a comprehensive analysis without altering the protein product, maintaining its integrity by avoiding procedures like dilution. Enhanced by multiple detectors, AUC discriminates between proteinaceous and non-proteinaceous materials, aiding in precise identification. The technique addresses challenges posed by formulation buffers, using specific algorithms to mitigate inhomogeneous solvent effects due to excipients. AUC supports self-association behavior analysis over a broad concentration range, employing peptide bond absorbance or advanced detection methods to handle extreme concentrations.

Advanced Biomolecular Interaction Analysis System

Nanolytics GmbH specializes in the detection and characterization of biomolecular interactions, specifically focusing on protein-protein and protein-ligand interactions. Their innovative use of Analytical Ultracentrifugation (AUC) provides detailed insights into complex stoichiometries, dissociation constants, and reaction kinetics, crucial for biochemical and pharmacological research. The company's expertise extends to utilizing advanced multiplex analysis resources such as 4D AUC and AIDA, enabling in-depth analysis of multi-component systems. A case study highlighted their ability to analyze antibody-antigen interactions in a two-component mixture, showcasing the power of their multi-signal analysis. This allows for accurate determination of stoichiometry and apparent molar mass in complex mixtures, offering a robust toolset for researchers in drug development and therapeutic research. Their extensive experience and specialized algorithms ensure optimal analysis conditions and comprehensive interaction characterization.