Catalysis Solutions Brochure

Catalysis SolutionsMaking the Most of Your Chiral MoleculesAmazing where you can go2 Catalysis SolutionsProcess Development by Solvias.... From screening to process implementation: fast state-of-the-art answersProcess development, design and optimization of catalysis leads are a Solvias specialty. The development process often works in tandem with our screening efforts. Once we find a screening hit (or once you supply us with your hit), our experts will set out to develop that lead for implementation in your process. Experience counts in this area. This makes it possible to apply the most rational and direct approach in the development of your catalytic process, from mg screening and kg scale-up, to tech transfer into production tanks.Research Preclinical Phase Launch & MarketingYour (Chiral) API - Our Expertise Clinical PhasesHT ScreeningLigand & Catalysts SupplyProcess Development & OptimizationScale-Up Catalysis Solutions 3Process Development by Solvias.... From screening to process implementation: fast state-of-the-art answersHigh Throughput Screening for• Asymmetric homogeneous catalysis• Biocatalysis• Racemic resolution• CX-Coupling• Heterogeneous hydrogenationOur ServicesProcess Development and Production• Catalysts and ligands for commercial supply by Solvias• Optimization (semi-automated parallel autoclaves)• Fine tuning, quality risk and risk analysis (twenty-four 50 ml reactors permit very accurate fine tuning) • Scale-up and proof of concept (large selection of autoclaves, 100 ml-50l)• Kilo-scale production (high pressure reactors, 5l, 16l and 50l) 4 Catalysis SolutionsAccelerating Chemical (Process) Development with HTS TechnologyWithin the chemical development group, and as a critical component of process research, Solvias re-lies on the highly efficient High Throughput Screening platform. High Throughput Screening (HTS), combined with rational design of experiments (DOE), is a powerful tool for rapidly identifying reac-tion conditions that consist of multiple reaction parameters to be screened and optimized. With this strategy, a large experimental space and serendipity can be covered and exploited. Until now, these screening tools have been used most successfully with asymmetric homogeneous hydrogenation, CX-coupling, classical racemic resolution, carbonylation, hydroformylation, diastereomeric crystallization, biocatalysis development, kinetic resolution using transition metal catalysis, standard organic transformation (such as glycosidation) as well as customized screening capabilities in the rapidly growing area of organoca-talysis. This fast and cost effective screening solution can enhance the route selection process for any chiral and non chiral intermediate or API. We assist you in selecting the most economic and viable route taking your devel-opment stage into consideration. Complemented by scale-up and manufacturing capabilities for APIs up to clinical phase II, Solvias supports its customers during the entire chemical and analytical development process.Catalysis Solutions 5Solvias offers a flexible HTS screening arrangement that allows you to choose a 96-well standardized plate for your substrate and, if desired, modify the plate with your own choices. We view this research service as an ex-tension to your laboratory and wish to fit into your drug development process with maximum flexibility, quick results, and competitive pricing.Choice of six pre-designed HTS plates for the following general substrate types: Acrylic acid. Classic substrate. Enamide. Classic substrates including alpha- and beta-dehydroamino acids. Simple ketone. Typically methyl aryl ketones, alkyl aryl ketones, and ketones that lack a 2nd transition metal coordinating functional group. Classic a- or ß-keto ester substrates or close relative. Simple olefin. Tri- or tetra-substituted. Unprecedented. Substrates that have little or no literature precedent.Prepare for lightning fast resultsStandardized 96-well Plate Design• Choose between six ready-to-use standard plates designed for your substrateMaximal Flexibility• Substitute your own ligand choices• 150 ligands to choose from covering Solvias’ technical scale as well as patent free and third-party ligandsSpeed• Lightning fast resultsR'H,RCO2HCOOR''H, RNHCOR' COOR''R NHCOR''Ar ROR XO OR'RR'' HXR'COR''H,R3 4 521234561R'H,RCO2HCOOR''H, RNHCOR' COOR''R NHCOR''Ar ROR XO OR'RR'' HXR'COR''H,R HPLC analysis and result reporting HTS Analysis and Reporting Order Easy to get started Set up HTS Analytics Typically adapted from an HPLC method. Analysis time < 10 minutes Perform HTS Plate 96 reactions performed to customer specifications 1 Week6UnprecedentedR'H,RCO2HCOOR''H, RNHCOR' COOR''R NHCOR''Ar ROR XO OR'RR'' HXR'COR''H,RR'H,RCO2HCOOR''H, RNHCOR' COOR''R NHCOR''Ar ROR XO OR'RR'' HXR'COR''H,RR'H,RCO2HCOOR''H, RNHCOR' COOR''R NHCOR''Ar ROR XO OR'RR'' HXR'COR''H,RR'H,RCO2HCOOR''H, RNHCOR' COOR''R NHCOR''Ar ROR XO OR'RR'' HXR'COR''H,RPre-designed Plates forAsymmetric Hydrogenation6 Catalysis SolutionsSolvias’ portfolio of industrially proven ligands and catalysts is readily available for your process. We currently have > 700 chiral (non) proprietary technical scale and research ligands on stock for screening and process development (65% Solvias catalysts, 25 % foreign, 10 % patent free). Most prominent and successful ligand families such as Josiphos, Walphos, Mandyphos, Taniaphos, Ubaphox are readily available from gram to kg-quantities under an IP-included kg-price. For commercial processes, all Solvias ligands are licensed without any general restrictions and without any further obligation such as custom production agreements with Solvias. The ligands are sold with attractive IP models ranging from an ‘all-inclusive’ kg price (IP included) to a regular royalty based licensing model. A list of readily available chiral ligands is available at www.solvias.com/ligands. Solvias‘ extensive ligand libraryChiral LigandsDiscover our large ligand portfolioCatalysis Solutions 7Solvias‘ extensive ligand libraryChiral LigandsDiscover our large ligand portfolioBroad Ligand and Catalyst SelectionSolvias CX Coupling LigandsPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAcPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeSK-CC01 SK-CC02 JosiphosP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAccataCXium A cataCXium P cataCXium F cataCXium FNPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFe NPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFeNPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFe NPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFeNPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFeNPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFeNPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFe NPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFeJosiphos Walphos Taniaphos (Umicore)Mandyphos (Umicore)MeO-Biphep Butiphane POx UbaphoxNPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFeNPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFeNPRRPFeFeJosiphos Taniaphos(Umicore)R2PPR'2HCH3FePR'2HCH3PR2FeHR2PR'2PNMe2FeHArylR2P NMe2ArylHR2PMe2NFeMandyphos(Umicore)MeO-Biphep POxButiphane UbaphoxWalphosSolvias Chiral LigandsTrifer JoSPOphosChenphosP PS NORPPh2FeOOPR2PR2 ONOPPh2PhPhIr(COD)BarFPPHCH3RROR' H FeNPPNFeFeFeTrifer Chenphos JoSPOphosSolvias CX Coupling LigandsPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAcPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeSK-CC01 SK-CC02 JosiphosP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAccataCXium A cataCXium P cataCXium F cataCXium FSolvias CX Coupling LigandsPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAcPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeSK-CC01 SK-CC02 JosiphosP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAccataCXium A cataCXium P cataCXium F cataCXium FSK-CC01 SK-CC02 JosiphosSolvias CX Coupling LigandsPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAcPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeSK-CC01 SK-CC02 JosiphosP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAccataCXium A cataCXium P cataCXium F cataCXium FSolvias CX Coupling LigandsPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAcPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeSK-CC01 SK-CC02 JosiphosP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAccataCXium A cataCXium P cataCXium F cataCXium FSolvias CX Coupling LigandsPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAcPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeSK-CC01 SK-CC02 JosiphosP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAccataCXium A cataCXium P cataCXium F cataCXium FcataCXium A cataCXium P cataCXium FSolvias CX Coupling LigandsPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAcPdNPHClPdNClPHFeR2PP(t-Bu)2HCH3FeSK-CC01 SK-CC02 JosiphosP RR'PR2ArN PR2PdPo-Tolo-TolPdPo-Tolo-TolOAcOAccataCXium A cataCXium P cataCXium F cataCXium FcataCXium FSolvias Chiral LigandsSolvias CX Coupling LigandsTel. +41 61 845 60 00Fax +41 61 845 69 00info@solvias.comwww.solvias.comTel. +1 201 302 6084Toll free 866 4 SOLVIASor 866 4 765 84 27Fax +1 201 302 6062Contact HeadquartersSolvias AGRömerpark 24303 KaiseraugstSwitzerlandContact Northern AmericaSolvias Inc.2125 Center AvenueSuite 507, Fort LeeNew Jersey, 07024USA01.12.6e