Laboratory Reagents Articles

Production of trimeric SARS-CoV-2 spike protein by CHO cells for serological COVID-19 testing

Soon after the genetic sequence of SARS-CoV-2 was determined in January 2020, there was a rush to develop rapid diagnostics for the disease. The World Health Organization issued early guidance and protocols for the use of PCR to assist in diagnosing the disease. However, drawbacks like long turnaround times and invasive sampling for PCR tests led to a concerted push to develop rapid antibody ...

Jan. 14, 2021

By 908 Devices Inc.
The race to a vaccine - unintended consequences?

A gold rush is on to find a vaccine for COVID-19. According to the World Health Association (WHO) in early May, there are more than 100 projects around the world centered on the development of a vaccine for the coronavirus. Eight candidate vaccines are already being tested in people in clinical trials. Once an effective vaccine (or vaccines) has been identified, it will need to be produced ...

Jun. 4, 2020

By Vistex Inc
Chloroquine diphosphate

Chloroquine (diphosphate) is an antimalarial and anti-inflammatory drug widely used to treat malaria and rheumatoid arthritis. Chloroquine is an inhibitor of autophagy and toll-like receptors (TLRs). MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and ...

Aug. 13, 2019

By MedChemExpress LLC (MCE)
Y-27632

Y-27632 is an ATP-competitive inhibitor of ROCK-I and ROCK-II, with Ki of 220 nM and 300 nM for ROCK-I and ROCK-II, respectively, which primes human induced pluripotent stem cells (hIPSCs) to selectively differentiate towards mesendodermal lineage via epithelial-mesenchymal transition-like modulation.MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals ...

Aug. 11, 2019

By MedChemExpress LLC (MCE)
IPI549

IPI549 is a potent and selective PI3Kγ inhibitor with an IC50 of 16 nM.MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and technical support teams with years of experience in the ...

Aug. 3, 2019

By MedChemExpress LLC (MCE)
Phorbol 12-myristate 13-acetate(PMA)

Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is an activator of SphK through protein kinase C (PKC) activation. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and ...

Jul. 31, 2019

By MedChemExpress LLC (MCE)
Olmutinib(HM61713, BI 1482694)

Olmutinib (HM61713, BI-1482694) is an irreversible EGFR tyrosine kinase inhibitor that binds to a cysteine residue near the kinase domain. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer ...

Jul. 30, 2019

By MedChemExpress LLC (MCE)
MRT68921 dihydrochloride

MRT68921 dihydrochloride is the most potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and ...

Jul. 28, 2019

By MedChemExpress LLC (MCE)
MP-A08

MP-A08 is a highly selective ATP competitive sphingosine kinase (SK) inhibitor that targets both SphK1 and SphK2 with Kivalues of 6.9 ± 0.8 μM and 27 ± 3 μM, respectively. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and ...

Jul. 26, 2019

By MedChemExpress LLC (MCE)
OICR-9429

OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction with IC50 of 5 uM. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and technical support teams with years ...

Jul. 25, 2019

By MedChemExpress LLC (MCE)
Branaplam(LMI070,NVS-SM1)

Branaplam (LMI070) is a highly potent, selective and orally active small molecule SMN2 splicing modulator. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and technical support ...

Jul. 17, 2019

By MedChemExpress LLC (MCE)
Mirogabalin(DS5565)

Mirogabalin (DS-5565) is a novel, preferentially selective α2δ-1 ligand characterized by high potency and selectivity to the α2δ-1 subunit of voltage-sensitive calcium channel complexes in the CNS. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural ...

Jul. 16, 2019

By MedChemExpress LLC (MCE)
BAY1125976

BAY1125976 is a selective allosteric Akt1/Akt2 inhibitor, inhibits Akt1 and Akt2 activity with IC50 values of 5.2 nM and 18 nM at 10 μM ATP, respectively. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and ...

Jul. 13, 2019

By MedChemExpress LLC (MCE)
MRT68921

MRT68921 is the most potent inhibitor of ULK1 and ULK2, with IC50 values of 2.9 nM and 1.1 nM, respectively. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and technical support ...

Jul. 12, 2019

By MedChemExpress LLC (MCE)
Glesatinib hydrochloride(MGCD265 hydrochloride)

Glesatinib hydrochloride is an inhibitor of the MET and Axl receptor tyrosine kinase pathways, which drive tumour growth when altered. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer ...

Jul. 6, 2019

By MedChemExpress LLC (MCE)
Mivebresib(ABBV-075)

Mivebresib is a potent and orally available bromodomain and extraterminal domain (BET) bromodomain inhibitor. Mivebresib binds to BRD4 with a Ki of 1.5 nM.MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and ...

Jun. 18, 2019

By MedChemExpress LLC (MCE)
AZD0156

AZD0156 is an oral, potent and selective ATM inhibitor with an IC50 of 0.58 nM. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and technical support teams with years of experience ...

Jun. 17, 2019

By MedChemExpress LLC (MCE)
SKF-96365 hydrochloride

SKF-96365 hydrochloride is a non-selective TRP Channel blocker. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and technical support teams with years of experience in the life ...

Jun. 12, 2019

By MedChemExpress LLC (MCE)
BAY-876

BAY-876 is an oral and selective GLUT1 inhibitor with an IC50 of 2 nM. BAY-876 shows good metabolic stability in vitro and high oral bioavailability in vivo. BAY-876 is sufficient to block basal and stress-regulated glycolysis, anchorage-dependent and independent growth of ovarian cancer cells.MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including ...

Jun. 11, 2019

By MedChemExpress LLC (MCE)
S63845

S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a Kd of 0.19 nM for human MCL1. MedChemExpress (MCE) offers a wide range of high quality research chemicals and biochemicals including novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. MCE has knowledgeable and friendly customer service and technical support ...

Jun. 11, 2019

By MedChemExpress LLC (MCE)

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