UPLC Articles

  • Identification and risk assessment of human and veterinary antibiotics in the wastewater treatment plants and the adjacent sea in Tunisia

    In the following study, we came up with and validated a prompt, sensitive and precise method for the simultaneous determination of 56 antimicrobial drugs (tetracyclines, sulfonamides, β-lactams, macrolides and quinolones) using the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was implemented with success to determine antibiotics in samples ...


    By IWA Publishing

  • Photodegradation of the benzothiostrobin in solution and on soil and glass surface

    The photolytic characteristics of benzothiostrobin were investigated in solution and on soil and glass surface. The main influence factors such as initial concentration, organic solvent and the aqueous environmental substances, including NO2–, NO3–, Fe2+, Fe3+, H2O2 and turbidity were investigated. Three photodegradation ...


    By IWA Publishing

  • How Water Treatment Plants Protect Fish from Disruptive Synthetic Hormones

    Scottish Water provides 1.34 billion liters of drinking water every day and takes away 847 million liters of waste water daily. Answerable to both the Scottish Parliament and the people of Scotland, Scottish Water recognizes that innovation is a key enabler for them to deliver sustainable, high-quality water treatment services. One of the many compounds they ...


    By Waters Corporation

  • Building a Perfect Purification Platform

    Dart NeuroScience is one of the largest privately owned biotech companies in San Diego with around 250 employees – and we have an interesting focus: memory. More specifically, our aim is to develop new technologies and therapies that can maintain or improve memory function and cognitive vitality. Much of our research is built on the work of ...


    By Waters Corporation

  • Ultra-Pure Proof with Mass Detection

    Before joining the newly formed Reach Separations in February 2012, I spent five years at AstraZeneca in analysis and purification (latterly as group lead in reversed phase and chiral purification). This experience gives me a good perspective of both the needs of “big pharma” and, more recently, the needs of a specialist separation solution provider. My ...


    By Waters Corporation

  • Webinar Recap: “Developing, Testing, and Troubleshooting Chromatography Method Transfer”

    Hi, I’m Tom Wheat, Principal Scientist at Waters, and I recently hosted a webinar entitled, “Developing, Testing and Troubleshooting Chromatography Method Transfer.” Over the course of the webinar, we discussed the transfer of chromatographic methods that occurs at many stages in the development and production of a product. In its simplest form, the method is moved from one ...


    By Waters Corporation

  • Get Empowered: Quickstart Interface - Tip #1

    Welcome back to Get Empowered! My tip-of-the-week blog for Empower Software kicks-off by taking a closer look at the Empower QuickStart Interface. There is so much to cover in this series, so I have broken it up in to three tips. Tip #1: An Overview ...


    By Waters Corporation

  • Advancing Omics Research and Reducing Bias with New MS Technology for Data-Independent Acquisition Experiments

    Targeted LC-MS based assays are increasingly applied in the post-discovery Omics area with an emphasis on validation, the first of many phases in translational research; and in studies that are aimed at gaining the understanding of biological systems in terms of drug development and treatment. Understanding the context of analytical results is driving current research, and therefore driving the ...


    By Waters Corporation

  • Webinar Highlights: Microfluidics for macromolecules

    Hi, I’m Jim Murphy, Principal Consulting Chemist at Waters, and I recently collaborated with Lucinda (Cohen) Hittle to present an exciting webinar on the use of microflow chromatography for macromolecules.  Lucinda, a Director of Discovery Bioanalytics at Merck, presented an overview of the use of LC-MS for peptide analysis along with various case studies for in vitro and in vivo ...


    By Waters Corporation

  • Tips to maintain your HPLC & UHPLC systems and columns

    Recently, Ade Kujore (Cecil Instruments), Tracie Brombos (GenTech Scientific) and I were asked by Angelo De Palma, a well-respected writer for Lab Manager magazine, to contribute to an article about maintaining and caring about your laboratory instruments. Here are my tips/best practices for column and HPLC/UHPC/UPLC system maintenance. Maintaining your ...


    By Waters Corporation

  • Is Microflow LC a Reality or Perception?

    Microflow or nanoflow chromatography has been used mostly in the academic and fundamental research environment in the past for its various advantages over analytical liquid chromatography, but rarely in the industrial settings. This is most likely because many of us believe it is a pain-in-the-neck technique to perform! But is this a reality or just a ...


    By Waters Corporation

  • Chivas Brothers Limited - Case Study

    Name: Alan Rettie Job title: Development Chemist Company: Chivas Brothers Limited (UK) ...

  • Alderley Analytical - Case Study

    Name: Sally Hannam Job Title: Director of Science Company: Alderley Analytical Ltd Alderley Analytical Ltd is based at the Alderley Science Park Bioanalytics with a touch of Genius Alderley ...

  • The Advantages of a Targeted 2D LC Approach

    Webinar Highlights | Focus on the Relevant: The Advantages of a Targeted 2D Chromatography Approach Hi folks, I’m Daniel Root, Senior Product Marketing Manager for Multidimensional LC Systems at Waters. I recently conducted a webinar that addressed multidimensional liquid chromatography – an exceptional tool for the improvement of characterization and separation of ...


    By Waters Corporation

  • Oxidative transformation of oxcarbazepine by Cl2, ClO2 and O3: characteristics and pathways

    In this research, the degradation efficiency, mechanism and intermediates’ toxicities of oxcarbazepine (OXC) upon chlorination, chlorine dioxide oxidation and ozonation were investigated. Results showed that three degradation approaches followed second-order kinetics, and ozonation had the highest removal efficiency both of OXC and dissolved organic carbon (DOC). Reaction intermediates were ...


    By IWA Publishing

  • High-throughput Microscale Bioanalysis is not a Paradox

    Question: When someone says microscale chromatography, what comes to mind? Increased sensitivity? Reduced sample volume? Enhanced MS sampling efficiency? Yes, yes, and yes! You might also say, “finicky,” “slow,” or “only one person in our group knows how to use it!” Maybe even, “there’s no way I can successfully transfer that method, so why ...


    By Waters Corporation

  • Simon Fraser University Opens Suite of Mass Spectrometers for Natural Products Discovery Research

    As a graduate student at the University of British Columbia, Dr. Roger Linington discovered his future life’s work serendipitously. While studying sponges, it became clear to him that one of the challenges in studying macroorganisms is their limited or slowly replenishing supply. To perform mechanism and mode-of-action studies, he needed a larger, more accessible source of ...


    By Waters Corporation

  • Assessing the mutagenic effect potential of pharmaceuticals and of their transformation products. Implications in the gene expression profiling

    The selection and prioritization of pharmaceuticals and of their transformation products for evaluating effects on the environment and human health is a challenging task. Both compound‐ (e.g. mixture composition, concentrations) and biological‐ (e.g. relevant endpoint, biological organizational level) oriented approaches applied for tackling these issues often resemble a Lernaean hydra by ...


    By John Wiley & Sons, Ltd.

  • ACQUITY Arc System: Transferring Validated HPLC Methods within USP Guidelines

    The thought of transferring established high performance liquid chromatography (HPLC) methods onto a another vendor’s LC, or a new platform like UHPLC/UPLC, may cause a bit of anxiety for those that may be unaware of how easy it can be. The reason that the topic of analytical method transfer induces so much angst is that for the transfer of an LC method to succeed, the method has to work as ...


    By Waters Corporation

  • What do an ancient Chinese Ruler and Waters’ Mass Spectrometry Research Team have in common?

    Tea is very important to them! If Waters Wilmslow ran out of tea it is likely the MS Research Team would struggle to function. The ancient Chinese Ruler, Emperor Jing Di, took tea to the grave with him for a cuppa in the afterlife. Many treasures were found in his tomb including; food, weapons, ceramic animals, and a full size chariot with horses. The discovery included several food items; ...


    By Waters Corporation

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