Bangs Laboratories - Coupling Procedure for Attaching Oligonucleotides to BioMag Carboxyl

BioMag® Carboxyl consists of an aqueous suspension of magnetic iron oxide particles coated to provide carboxyl groups. The carboxyl groups are sterically unencumbered, permitting the covalent attachment of oligonucleotides with retention of biological activity for molecular biology applications. There are about 4.8μmoles of carboxyl per mL (240 μmoles per gram).