YMC - Model CUBE -Flagship Chromatography System

Resolution: Analytical resolution at preparative scale

• Ideally suited for monoclonal antibody purification and difficult separation challenges
• Batch chromatography processes
• Two-step integrated batch chromatography processes
• CaptureSMB for optimized capture
• AutomAb program for optimization of CaptureSMB
• MCSGP for polishing
• N-Rich® for isolation of product-related impurities

MCSGP, being the only scalable ternary chromatographic process solution, offers large economic benefits compared to batch processes, which have an intrinsic weakness of having to choose between yield and purity. With MCSGP processes, both yield and purity are always superior compared to an analogous batch process and, in addition, productivity is increased up to tenfold while buffer/solvent consumption is reduced by 70%. MCSGP processes can be run with smaller equipment footprints, offering large CAPEX and OPEX savings. A single polish step of a biopharmaceutical product employing MCSGP could save up to 4 mio USD p.a.

N-Rich® enables the enrichment of a minor compound while simultaneously depleting the large excess of interfering components. It is particularly useful for the isolation of product-related impurities and saves tedious repetitive analytical separations to isolate the compound of interest. With N-Rich®, this can be achieved in a short time without repetitive manual handling.