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HiSense - Gas Analysis System
Unlike conventional exhaust gas analysis, the HiSense™ analysis systems from HiTec Zang also offer the biological variables OTR, CTR and RQ. The devices are suited for R&D and laboratory applications and for production and quality assurance.
Sensors are used for oxygen analysis which are distinguished by their low interference, low-noise readings and high long-term stability.
NDIR photometers with a minimum of zero and increase errors are used for the CO2 measurement. Through a new form of special measuring method even the precise measurement of very low activity both for small differences and for small measured gas flows are possible.
- 2 to 5 measuring channels for up to 4 fermenters with a common gas feed or 2 fermenters with separate gas feeds
- High-resolution measurement (HiSense™-c)
- Humidity correction / gas drying (HiSense™-c)
- "Genuine" OUR, CER and RQ measurement (HiSense™-c)
- Low interference
- Overpressure possible
- Wear-free sensors
- Compact
- Additional functions can be integrated
- Optionally freely programmable
- Many possibilities for couplings
- Data export
In the cell culture version the correction of unavoidable influences such as overall pressure, humidity etc. with a high degree of accuracy is enabled thanks to additional measuring equipment and offsetting. The influences may be very large in conventional exhaust gas analysis, low metabolic rates and long cultivation periods and may make a comparison of cultivations more difficult or even impossible, meaning that the use of exhaust gas analysis for quality assurance becomes impossible. Not until the influence variables have been corrected is it possible to gain meaningful readings.
The HiSense™-c precision gas analysis system for cell culture and fermentation applications additionally provides an online determination of the true CO2 production (CER) in the carbonate buffer systems normally found in a cell culture (optional pH input required). In addition, the errors are corrected which make valid measurements impossible as a consequence of the shifting of the HCO3 /CO2 balance by metabolic products (e. g. lactate, NH3 ). Only in this way is a determination of the actual RQ possible.
The high measuring resolution enables meaningful measurements under normal conditions, even for the low breathing rates of animal cell cultures and in a very broad range (reactor volumes of 1 l up to more than 100,000 l), depending on the model.
The software carries out all calculations online including all corrections. All readings are saved in a database and may be progressively displayed on the x-t plotter.
An export as a file (csv, txt and other formats) is possible.