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IDT Biologika - Single-Use Stirred Tank Bioreactors (STRs)
Single use stirred tank reactors (STRs) are another well-established incubation vessel for cell culturing in live virus manufacturing. At IDT Biologika, the STR technology can be used for both suspension culture and adherent culture. For adherent cell culture, Microcarrier Technology is utilized to provide a very large surface area for the attachment and growth of cells. Adherent cells require a large surface area, and this approach provides an environment for efficient virus harvest.
The larger the surface area, the more cells can be incubated, so space-time yields tend to be higher than cell factories. Other benefits include minimal operator intervention and elimination of some cleaning, sterilization, and validation requirements, mitigating the risk of contamination and optimizing purity. Single-use STRs also reduce mixing times and can optimize the processing time overall, so they are a key technology in viral vaccines and vectors.
As referenced above, IDT Biologika uses microcarrier technology in conjunction with stirred tank bioreactors in cell culturing. The cells grow on surfaces and in the case of microcarriers, they are small particles that contain a certain number of cells where the virus can grow. The microcarrier structures create a very large surface area, so they optimize the number of cells that can grow in the reactor and consequently the amount of virus that is produced.