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Genizer LLC
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Genizer - Jacketed Liposome Extruders

Genizer - Jacketed Liposome Extruders

FromGenizer LLC

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The Genizer Jacketed Liposome Extruders is compressed air-driven and temperature-controlled, from testing to manufacturing production of liposome and lipopolyplex, for drug and gene delivery. Homogenous samples can be produced quickly and easily in minutes; typically 5-10 passes are sufficient to produce a sample with uniform liposome size. Genizer Jacketed Liposome Extruders are designed to generate homogeneous unilamellar liposomes and Lipopolyplex. Extrusion is a one-step procedure that produces liposomes by forcing lipid suspensions of drug, protein or gene through track-etched filters of defined pore size. The process is relatively gentle, exposing the formulation to moderate pressures up to 3,000 psi at controlled temperatures. The Genizer Jacketed Extruder offers virtually no dead-volume, is easy to clean, suitable for sterilization and in compliance with FDA and GMP sanitary standards in pharmaceuticals.

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Application:

Liposome extrusion

Performance:

No dead volume

The Jacketed Extruder can control the temperature of the extrusion

Specifications

Catalog No. GJE-10mL GJE-100mL GJE-800mL GJE-3000mL GJE-10000mL

Sample Size 10mL 100mL 800mL 3,000mL 10,000mL

Cooling Jacketed Jacketed Jacketed Jacketed Jacketed

Dimensions 23cm×13cm×25cm 23cm×20cm×32cm 25cm×25cm×37cm 30cm×25cm×55cm 45cm×40cm×65cm

Weight 4kg 7kg 20kg 45kg 120kg

Min. Sample Size 5mL 10mL 120mL 800mL 2,000mL

Application Liposome formulation up to production scale

Max. Pressure 3,000 psi-6,000 psi

Max. Temp. 80ºC (176ºF)

Power Type Compressed gas

Nano-membrane Track-etched membrane

Cleaning Flush to clean/CIP/SIP

Sterilization Whole unit autoclavable

Standard Features

Parts 1) Liposome Jacketed Extruder 2) 10 pieces of 100nm membrane

Feed Reservoir Temperature-controled jacketed cylinder

Inlet Type 1/4" high pressure coupling

Outlet Type 1/4" high pressure coupling

Nitrogen Tubing G5/8" - 14 TPI BSP inlet nitrogen high pressure soft tubing; adaptor with

3/8-inch male NPT and 1/4-inch female flare outlet

Nano Membrane 100nm track-etched polycarbonate membrane

Compatibility Some parts are compatible with Lipex™ in Northern Lipids

Product Material 316L stainless steel, viton

Material Standard Pharmaceutical grade; compliantwith FDA and GMP sanitary standards

Warranty 1 year against any manufacturing defects

Option Features

Detector Pressure gauge, pressure transducer, temperature transducer

Inlet Type Tri-clamp or luer

Outlet Type Tri-clamp or luer

Nano Membrane 30, 50, 80, 130, 200, 400, 800nm, 1300nm, 2μm, 5μm, 10μm, 20μm, 30μm

track-etched membrane (25mm, 47mm, 90mm, 160mm, 293mm)

Multi Extruder Parallel or series connection of multi-extruder