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MedChemExpress - Model DL-dithiothreitol -3483-12-3
DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond[1][2].MCE products for research use only. We do not sell to patients.
DL-dithiothreitol
MCE China:DL-dithiothreitol
Brand:MedChemExpress (MCE)
Cat. No.HY-15917
CAS:3483-12-3
Synonyms:DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol
Purity:99.43%
Storage:4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Shipping:Room temperature in continental US; may vary elsewhere.
Description:DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond.
In Vitro:DL-dithiothreitol is widely used in biochemistry works to reduce dissulfide bridges, protect biomolecules, in sample preparation, and to denature proteins before electrophoresis analysis (SDS-PAGE). DL-dithiothreitol (0.5 mM) prevents dithiothreitol stress and inhibits dithiothreitol cell death in DLD-1 and HCT116 cells under glucose starvation[2].
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References:
[1]. Dithiothreitol, From Wikipedia
[2]. Yao H, et al. Establishment of disulfidptosis-related LncRNA signature as biomarkers in colon adenocarcinoma[J]. Cancer Cell International, 2024, 24(1): 183. [Content Brief]
Brand introduction:
• MCE (MedChemExpress) has a global exclusive compound library of more than 200 kinds, and we are committed to providing the most comprehensive range of high-quality small molecule active compounds for scientific research customers around the world;
• More than 50,000 highly selective inhibitors and agonists are involved in various popular signaling pathways and disease areas;
• The products cover a variety of recombinant proteins, peptides, commonly used kits, more PROTAC, ADC and other characteristic products, widely used in new drug research and development, life science and other scientific research projects;
• Provide virtual screening, ion channel screening, metabolomics analysis detection analysis, drug screening and other professional technical services;
• It has a professional experimental center and strict quality control and verification system;
• Provide LC/MS, NMR, HPLC, chiral analysis, elemental analysis and other quality inspection reports to ensure the high purity and high quality of products;
• The biological activity of the products has been verified by the experiments of customers in various countries;
• A variety of top journals such as Nature, Cell, Science and pharmaceutical patents have included the scientific research results of MCE customers;
• Our professional team tracks the latest pharmaceutical and life science research and provides you with the latest active compounds in the world;
• It has established long-term cooperation with the world's major pharmaceutical companies and well-known scientific research institutions。
