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MedChemExpressModel DL-dithiothreitol -3483-12-3

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DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond[1][2].
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DL-dithiothreitol

MCE China:DL-dithiothreitol

Brand:MedChemExpress (MCE)

Cat. No.HY-15917

CAS:3483-12-3

Synonyms:DTT; rel-(2R,3R)-1,4-Dimercapto-2,3-butanediol

Purity:99.43%

Storage:4°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Shipping:Room temperature in continental US; may vary elsewhere.

Description:DL-dithiothreitol (DTT) is a strong reductant with anti-disulfidptosis activity. When DL-dithiothreitol is oxidized, it forms a stable six-membered ring with an internal disulfide bond.

In Vitro:DL-dithiothreitol is widely used in biochemistry works to reduce dissulfide bridges, protect biomolecules, in sample preparation, and to denature proteins before electrophoresis analysis (SDS-PAGE). DL-dithiothreitol (0.5 mM) prevents dithiothreitol stress and inhibits dithiothreitol cell death in DLD-1 and HCT116 cells under glucose starvation[2].

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References:

[1]. Dithiothreitol, From Wikipedia

[2]. Yao H, et al. Establishment of disulfidptosis-related LncRNA signature as biomarkers in colon adenocarcinoma[J]. Cancer Cell International, 2024, 24(1): 183.  [Content Brief]

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