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Pro-Mill - Solid Phase Bioreactors
Pro-mill’s solid phase bioreactor is used to carry out biotech processes on solid substrate. The installation is mounted on a SKID frame and has all the necessary equipment for the process. The solid phase reactor consists of a main vessel and a set of mixers designed for the specific application. The main reaction occurs on the solid material filling the tank. The solids are kept at an appropriate humidity level. The main tank is also thermostated to ensure the best possible process conditions. In order to start the growth of the microorganisms, nutrient solution and inoculum are dosed into the tank.
The whole installation consists of several parts:
- Preparation of the inlet air – the air passes through a pre-filter and a high-precision bacteriostatic air filter. The filtrated stream is used to aerate the reactor content;
- Thermostat – serves to maintain a constant temperature inside the tank, which is necessary to carry out the process of growth of microorganisms;
- Outlet air system – the outlet air from the tank is cooled and then filtered on a bacteriostatic air filter of high precision. Process parameters such as CO2 and O2 content are also measured.
- Sterile nutrient solution and inoculum dosing system;
- RO water dosing system – water passes through a pre-filter and goes to the bioreactor in order to keep the bed moisture;
- Clean-In-Place washing loop – to thoroughly wash out residues and sterilize the required bioreactor areas.
The solid-phase bioreactor is equipped with the necessary control and measurement equipment and a control cabinet allowing for programming the process flow, viewing and archiving of current process values and even communication with an external SCADA system. This type of installation can be integrated with the existing technological line or used as an increase in the scale of the existing process.
Bioreactors manufactured by Pro-mill can be designed to meet individual customer needs.
Functions of solid phase bioreactors:
- Process-oriented design
- Type of mixer selected for specific application
- Control of temperature, humidity, airflow
- Necessary control and measuring equipment
- Adapted for CIP/SIP
- Control from the PLC
- Archiving, communication with SCADA