Vala - Model Cat. 4856 -Anti-P-Perilipin 1-Serine 522 Antibody Reagent

Background:  Lipid droplets are coated with a layer of proteins that regulate their growth and metabolism.  The major lipid droplet-associated protein in adipocytes is perilipin [1].  Mice in which the endogenous gene for perilipin is knocked out have a lean phenotype due to reduced accumulation of fat [2,3], suggesting that perilipin may have a “gate-keeper” function under basal conditions to protect the triglycerides from metabolism by lipases.  Upon activation of lipolytic pathways, perilipin is subject to phosphorylation at serine 497 and 522 by cyclic-AMP-dependent protein kinase, and phosphorylation of perilipin helps to recruit hormone sensitive lipase (HSL) to the lipid droplets. Amount:  100 µL.