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Crystallization Development - From Screening to Kilogram Supply
FromSolvias AG
Solvias offers a seamless approach to design and optimize a robust and scalable crystallization process together with kilogram supply of API under GMP, if required:
Polymorphism Investigation
- Determination of relevant polymorphic forms
- Evaluation of polymorphic transformations
- Identification of thermodynamic most stable form
Form Selection & Process Design
- Temperature-dependent solubility
- Identification of metastable zone width
- Variation of crystallization techniques, solvents, process parameters
Crystallization Process Optimization
- Optimization of process parameter and
- bulk properties
Multigram to Kilogram Supply
- Crystallization on kilogram scale
- (GMP/non-GMP)
- Technical transfer of crystallization process