Proteros Biostructures GmbH
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X-Ray Crystallography Services
We offer three types of Protein X-Ray Crystallography Services.
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X-ray analysis
protein structure
humidity control
structural protein analysis
biophysics
protein analysis
process automation
GALLERY STRUCTURES
- > 200 relevant targets ready for Protein-Ligand-Structure determination
- Saving valuable time through pre-defined protein production, purification, analytics and crystallization conditions
- From construct design, protein production, broad crystallization screen, optimization of crystals for high-resolution structure, Synchrotron data collection, to structure solution and refinement
- High-resolution protein-ligand-structures (PLS) or apo structures
- Initial screening only
- Crystal optimization only (incl. Free Mounting System "FMS")
- Data collection (Synchrotron) only
- Structure solution /refinement only
PROTEIN FOR CRYSTALLIZATION
- Establishment of protein production
- Biophysical characterization of protein quality
- Deliverable: Protein satisfying the high-quality standards of crystallography
CRYSTALLIZATION
- up to 2000 initial crystallization conditions tested in parallel
- Reliable drop setting using robotic platform
- Automated imaging systems at 4°C and 20°C
- In-house x-ray facility to test crystals
- Established protocols for LCP and robotic LCP drop setting
- Deliverable: Protein crystals suitable for x-ray
DATA QUALITY ENHANCEMENT
- Humidity controlled improvement of data quality
- Advanced laser controlled improvement of data - FMS laser
- In-house rotating anode X-ray analysis for crystal evaluation
- Deliverable: Protein crystals optimized for high-resolution crystallography
STRUCTURAL ANALYSIS
- Data collection at the SLS beamline
- Automated pipeline for data processing and structure solution (MIR/MAD/SAD and Molecular Replacement)
- Stringent quality control process for all structures delivered (PDB standard)
- Deliverable: High-resolution protein (apo) or protein-ligand-structure (PLS) crystal