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Ion Channel Research
Aurora Biomed - Model ICR 8000 - Ion Channel Reader
Invaluable for ion channel screening, the ICR 8000 detects ion channel activity using atomic absorption spectroscopy and flux assays. Current applications include the evaluation of the hERG potassium channel more quickly, more precisely and more accurately than other medium to high throughput ion channel screening systems. Interactions with the hERG channel can lead to prolonged QT syndrome, thus, regulatory agencies require the assessment of QT liability.
Aurora Biomed - Model ICR 12000 - Ion Channel Reader
Based upon the versatility, precision, and sensitivity of atomic absorption spectroscopy (AAS) and Aurora Biomed’s patented microsampling process, the ICR 12000 is suitable for both ligand-gated and voltage-gated ion channels using cell-based flux assays. The ICR 12000 was designed for ultra high throughput ion channel screening of compound libraries against ion channel targets. Based on the robustness of Aurora Biomed’s ICR technology, the reader offers high sensitivity generating accurate drug rank order matching electrophysiology data. This new member of the ICR ion channel screening series provides the throughput to access compound QT liability early in the drug discovery process.
Aurora Biomed - Ion Channel Screening Assays
Aurora Biomed provides a wide range of ion channel assays to quickly and accurately provide results for drug discovery and development research worldwide. A convenient, integrated ordering system facilitates rapid assessment and processing of globally standardized tests. Assays are performed manually by patch clamp or by Qpatch. Cold flux assays are also available for limited compounds or candidates that cannot be screened with manual-patch clamp, with a strong linear correlation (R=0.88) and consistently identical drug rank orders between the cold flux and patch clamp methods. This method relies on non-radioactive trace ions measured by Aurora’s high-throughput proprietary atomic absorbance-based Ion Channel Reader series: ICR 8000 and ICR 12000Aurora Biomed - Ion Channel Screening Cell Lines
Aurora Biomed offers cell lines for purchasing and licensing for some of the most common drug discovery ion channel targets. The cell line collection includes stably expressed hERG potassium channels, Kv1.3 potassium channels, or Nav1.5 sodium channels, each optimized and validated using both flux assays and electrophysiology. The window of detection (signal/noise) of these cell lines is appropriate for high-throughput screens. Use with Aurora Biomed’s Ion Channel Reader Series and optimized reagents, can generate robust, sensitive assays for ion channel screening.