KNIK products

The 100L bioreactor system is designed for vaccine production, offering a comprehensive suite of features tailored for high-precision fermentation processes. Its vessel capacity is 100 liters, with a working volume ranging between 70% to 75%, and crafted from stainless steel 316L, renowned for its durability and resistance to corrosion. The inner vessel surface is polished to a roughness average of ≤0.4 um, while the jacket has an external surface precision of ≤1.2 micron, built to withstand pressures of 0.1 to 0.35 Mpa. This system supports advanced sterilization via a steam-water separator integrated into the primary steam conduit, allowing for efficient sterilization protocols. The stirring mechanism employs an SEW AC motor with variable frequency control for speeds between 50 to 1000 rpm. Additionally, it features an intelligent PID control system for consistent pH and DO regulation, ensuring optimal conditions for the fermentation process.

This customized bioreactor system is designed for biological fermentation manufacturing, catering to research, development, pilot, and production needs. With a working volume ranging from 1000 to 10000 liters, the system is constructed primarily from durable 316L stainless steel, complemented by 304 stainless steel components. It features a sophisticated control system using Siemens PLC, an industrial LCD touch computer, allowing parameter settings to be stored and remote connectivity through USB. The design supports an internal and interlayer pressure of 0.3Mpa, with superior polishing precision at Ra0.4-0.6 and a height-to-diameter ratio of 1:2.3. The apparatus includes an advanced mechanical seal stirring system, offering variable speeds between 70 to 1200 rpm. The bioreactor is equipped with autocontrol mechanisms for temperature, pH, DO, and pressure, utilizing high-quality components from Denmark, the U.S., and Switzerland for precise control. Manufacturing is based in China, supplying various fermentation equipment including stainless steel and glass fermentors.

Solid state fermentation (SSF) is recognized for its cost-effectiveness and environmental benefits over submerged liquid fermentation (SLF). This process is prominent in producing value-added industrial products like enzymes and biofuels. The SSF method presents both advantages and disadvantages compared to SLF, and involves microorganisms that are crucial for its success. The characteristics of bioreactors tailored for SSF play a significant role in optimizing the process. This fermentation method is not only essential in industrial applications but also finds its utility in the agro-food industry and environmental management. The review consolidates current advancements in SSF while exploring multilayer drawer discharge systems and pulse pressure systems, which enhance operational efficiency.

The KNIKBIO-XV series 200L Diphtheria Vaccine Bioreactor is a specialized device engineered for the cultivation of bacterial vaccines. The system is fully sealed and features a double mechanical seal that effectively prevents bacterial contamination within the bioreactor tanks. It offers comprehensive monitoring of fermentation parameters such as pH, DO, temperature, and stirring speed, which can be controlled and transmitted via a user-friendly PLC system with a touch interface. The bioreactor is constructed from 316L stainless steel, ensuring ease of maintenance and longevity, with surfaces polished to a high standard. The design includes an advanced ventilation system with multichannel capabilities, using a thermal mass flow meter for precision control. Its mechanical stirring options provide stable and flexible operations, while its SIP and CIP systems offer automatic sterilization and cleaning. The optional features, such as fermentation broth weighing, add to the system's adaptability in precise bioprocesses.