Solvias AG services

The aim of a polymorphism screening is to search for, to identify and to characterize new polymorphic forms, hydrates and solvates of a substance, and to understand the relationship between the different solid phases. To reliably search for relevant polymorphs, solvates and hydrates, a systematic and smart planning is essential.

In a well-designed salt/co-crystal screening process, the optimal salt/co-crystal is chosen quickly, based on parameters such as solubility, hygroscopicity, crystallinity, chemical stability and suitability for production.

Accurate and sensitive determination of polymorphic purity in both drug substance and drug product, as well as the identification of the amorphous content in the drug substance, assures product quality and reliability. Based on the substance specifics, the best technique is selected to obtain the most sensitive levels of detection.

Solvias offers a seamless approach to design and optimize a robust and scalable crystallization process together with kilogram supply of API under GMP, if required: