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Izon - Model Exoid -Tunable Resistive Pulse Sensing (TRPS) System
Using Tunable Resistive Pulse Sensing (TRPS), the Exoid measures nanoparticles one-by-one as they pass through a tunable nanopore, allowing you to obtain measurements of particle size and concentration, or particle size and zeta potential, on a single-particle basis. Unlike ensemble techniques, where larger particles can skew size measurements, the Exoid provides insightful, high-resolution measurements that allow you to detect important differences in particle size distribution.
The Exoid: Versatile Measurement for Complex Samples
Based on the established TRPS platform, the Exoid measures particle size, concentration, and zeta potential on a particle-by-particle basis. Its tunable nanopores support a broad range of complex samples, delivering accurate, proven single-particle data you can trust.
Tunable Resistive Pulse Sensing (TRPS) measurements have in-built requirements which ensure a standardised approach to measurement:
Traceable calibration
Measurements are calibrated using Izon standards characterised against NIST particles, ensuring reproducible and comparable results.
Real-time system feedback
Live monitoring of current and noise helps maintain stable, high-quality measurements.
Buffer control checks
Running a particle-free buffer confirms that detected events represent true particles in the sample.
EV-ready workflow
Pair with qEV isolation to support consistent, standardised EV characterisation.
The Exoid enables detailed, single-particle analysis across a broad range of nanoparticle types. Measure particle size and concentration from 40 nm to 11 µm, and size and zeta potential from 40 nm to 2,000 nm, using interchangeable nanopores to match your sample.
Its wide dynamic range and tunable measurement conditions make it well suited to complex or heterogeneous samples, including extracellular vesicles, lipid nanoparticles, virus-like particles, and other biological or synthetic nanoparticles.
For researchers who require flexibility and depth of insight across diverse particle systems, the Exoid remains a trusted and versatile platform.
Over the years, TRPS instruments have evolved significantly, improving usability and workflow compared with earlier generations.
That said, the Exoid remains a hands-on platform. Users adjust measurement conditions and occasionally troubleshoot to maintain optimal performance, particularly when working with complex samples.
With training and experience, this level of control becomes a strength, enabling detailed analysis across a wide range of particle types.
Izon provides training and ongoing support to help users get the most from the system.
As particle size decreases, measurement becomes more technically demanding. Smaller particles require tighter control of conditions, careful calibration, and greater user skill to obtain reliable data.
The Exoid is designed to deliver precise, repeatable single-particle measurements across a wide size range, including challenging sub-100 nm particles. Achieving optimal results requires good sample preparation and active user oversight.
For experienced users who value flexibility and control, this involvement enables robust, defensible data, particularly at the smallest sizes.
- Analysis range: 40 nm to 11 µm
- Compatible electrolyte solutions: Include PBS, HEPES, MES and KCI
- Footprint: 300 x 300 mm
- Concentration range: 1E5 to 1E11 particles/mL (size-dependent)
- Weight: 10.8 kg
- Height: 250 mm