Raman Spectroscopy Solutions for Raw Material ID - Chemical & Pharmaceuticals - Pharmaceuticals
Raw material identification and verification is a regulatory requirement for pharmaceutical manufacturers. The use of Raman outside of pharmaceutical applications is growing rapidly. Raman instruments provide a molecular fingerprint of samples for nondestructive identification and verification of materials such as active pharmaceutical ingredients (APIs), excipients, intermediates, and finished products.
Raw Material ID Applications
While best known for its use on the loading dock of a pharmaceutical manufacturing site, Raman continues to expand into new markets. From chemical plants to polymers and plastics, read the following application notes to see how Raman raw material identification measurements are performed.
Using Handheld Raman to Reduce Risks in Materials Used for Manufacturing
Raman spectroscopy is a valuable tool for providing rapid, specific analysis for identifying raw materials, thus reducing the risk of using substandard or incorrect materials in manufacturing. The utility of handheld Raman increases productivity and the ability to do complete testing without creating bottlenecks in the production process.
Handheld Raman solutions have improved the ability to complete incoming raw material testing without sample preparation. The NanoRam handheld Raman contributes to increased quality testing with a cost-effective technology used at the point of receipt, thus minimizing steps to material acceptance, giving a high return on investment (ROI).
In this application note, the main ingredients of olive oil, camellia oil, arachis oil, sunflower seed oil, and colza oil are analyzed using a portable Raman spectrometer combined with chemometrics software.
Handheld Raman tests raw materials for different sample types and forms. Using optimized sampling accessories enhances the utility of handheld Raman without compromising data quality or complicating testing.
This article demonstrates the utility of portable Raman spectroscopy as a versatile tool for process analytical technology (PAT) for raw material identification, in-situ monitoring of reactions in developing active pharmaceutical ingredients (APIs), and real-time process monitoring. Raw material identification is done to verify starting materials as required by PIC/S and cGMP, and can be readily done with handheld Raman.