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by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs provide automatic and accurate N-terminal Edman sequencing service, based on HPLC and SHIMADZU PPSQ-33A ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
MtoZ Biolabs uses UPLC/TripleQuad5500 for analyzing multiple types of vitamins. With our utting-edge analytical platform, we can analyze over 70 types of ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein tandem mass spectrometry (MS/MS) is an efficient, precise, and sensitive method for qualitative and quantitative identification of proteins based on mass spectrometry technology. It is widely used in proteomics research, biopharmaceutical quality control, disease biomarker discovery, and other fields. By analyzing the peptide fragments (products of protein digestion) using mass ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein mutation refers to the alteration in the amino acid composition or sequence of a protein, which subsequently leads to changes in the structure and function of the protein. Protein mutations can occur naturally or be induced artificially. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
During the production of bioproducts, it's common to find impurities not only produced in the manufacturing process but also related to the desired products. These product-related impurities typically consist of product variants that do not align functionally with the target product. The most common variants arise from chemical modifications, as well as from the degradation and aggregation of the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Proteins found in nature vary in size from 5 kDa to 400 kDa. The protein hydrolysis process cuts proteins into shorter segments, namely peptides. Protein hydrolysis is a crucial step before peptide mass spectrometry identification analysis, providing a foundation for successful protein identification and characterization, as well as biomarker discovery. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Principal Component Analysis (Principal Component Analysis, PCA) is the linear recombination of all metabolites originally identified, forming a set of new comprehensive variables, and selecting 2-3 comprehensive variables from them based on the analyzed problem, to reflect as much information of the original variables as possible, thus achieving the purpose of dimension reduction. At the same ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Metatranscriptomics, also known as environmental transcriptomics, involves the comprehensive study of gene transcription and regulation within microbial communities in specific environments and stages to uncover how microorganisms adapt to varying environmental pressures and to explore the mechanisms of interaction between microorganisms and environments. It can be applied in human microecology, ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Hydrogen deuterium exchange mass spectrometry (HDX MS) represents a sophisticated technique in mass spectrometry for investigating the spatial conformation of proteins, extensively employed across academia and the biopharmaceutical industry for the analysis of protein structures. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Active Pharmaceutical Ingredients (APIs) are substances or mixtures employed in the production of drugs. They have pharmacological effects or directly contribute to diagnosing, treating, mitigating symptoms, controlling, or preventing diseases, in addition to influencing the structure or function of the body. ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein phosphorylation is a common post-translational modification in eukaryotes. Eukaryotic cell protein phosphorylation is divided into two types: serine (Ser)/threonine (Thr) phosphorylation and tyrosine (Tyr) phosphorylation. Although the proportion of Tyr phosphorylation is small, it plays an extremely important role in the fate of cells and individuals, and is closely related to diseases ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Tandem mass tags, TMT technology is a tandem mass spectrometry labeling technology developed by Thermo Company, mainly used for the identification and quantification of proteins in different samples. Each TMT labeling reagent consists of: an NHS-ester group with amine-reactive activity, a mass normalization group, and an MS/MS reporter group. The isotope label of each labeling reagent has the ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The transcriptome is the complete set of mRNA within a cell under specific developmental stages or physiological conditions. Transcriptome sequencing, as a technical means of studying the transcriptome, is widely used in biological science research. Analyzing the transcriptome information of biological samples helps in studying the gene transcription situation and transcriptional regulation ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The N-terminal sequence is closely related to the function and stability of proteins. The analysis of the N-terminal sequence of proteins can determine the starting point of proteins, which is conducive to the analysis of the higher-order structure of proteins and reveals the biological functions of proteins. The Edman degradation method removes amino acids from the N-terminal of proteins step by ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Immunoprecipitation (IP) technology is a method widely used in antigen purification and detection, which separates specific proteins from a solution by utilizing antibodies that can bind to the proteins. The technique involves removing antibody-protein complexes from the solution by adding insoluble forms of antibodies (such as those conjugated with agarose beads or the recently popularized ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Under physiological conditions, most protein interactions are transient, posing significant challenges for their study. Crosslinking reagents resolve this by covalently bonding interacting proteins, thereby capturing protein-protein complexes and preserving brief, weak interactions for easier separation and characterization. Researchers can perform crosslinking both in vivo and in vitro, choosing ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
In the biological activities of organisms, the function of proteins is achieved through interactions between proteins. Therefore, studying new protein interactions can provide new directions for investigating the potential functions of proteins. Among many protein interaction identification experiments, pull-down is commonly used for in vitro protein interaction testing, and helps discover new ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein purity and uniformity are crucial for protein crystallization as well as structural and functional studies. Impure samples can lead to inaccurate results in experiments. Additionally, protein purity and uniformity are two very important characteristics for further protein research and biopharmaceutical applications. The purity of protein samples limits the application of protein ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
Protein purity refers to the relative proportion of the target protein in a protein sample, typically expressed as percentage. The higher the purity, the higher the proportion of the target protein in the sample. Measuring protein purity is an important aspect of biochemistry, molecular biology, and biotechnology. By determining protein purity, the quality of the extracted protein sample can be ...
by:MtoZ Biolabs based in, MASSACHUSETTS (USA)
The utilization of the bottom-up approach in proteomics is often constrained by the incomplete characterization of alternatively spliced isoforms, a wide array of post-translational modifications, and native protein degradation. ...