Sample Preparation Articles

  • The productive environmental laboratory: BSK Labs boosts efficiency with Metrohm IC

    BSK Labs runs a number of environmental laboratories and service centers along the west coast of the US. A total of 70 employees – including microbiologists, chemists, lab technicians, and support staff – make sure that the 200 to 350 samples that come in every week are analyzed. BSK Labs specializes in potable water chemistry, ground water monitoring, storm water runoff, solid waste ...


    By Metrohm AG

  • Webinar Highlights: Microfluidics for macromolecules

    Hi, I’m Jim Murphy, Principal Consulting Chemist at Waters, and I recently collaborated with Lucinda (Cohen) Hittle to present an exciting webinar on the use of microflow chromatography for macromolecules.  Lucinda, a Director of Discovery Bioanalytics at Merck, presented an overview of the use of LC-MS for peptide analysis along with various case studies for in vitro and in vivo ...


    By Waters Corporation

  • Analysis of Trace Elements in Water by EPA Method 200.8 using ICP Mass Spectrometry

    This application note describes the methodology and use of the Shimadzu ICPMS-2030 ICP mass spectrometer for the analysis of trace elements in drinking and fresh waters following the EPA 200.8 method. This method is also used for analysis of wastewater. In-line addition of internal standards to calibration and unknown samples was accomplished using the Shimadzu Internal Standard Addition ...

  • Development of a Cleaning Validation Method for MICRO® A07 Citric Acid Cleaner Using HPLC-CAD

    Abstract A high performance liquid chromatography (HPLC) method with a Corona Charged Aerosol detector for the cleaning validation of MICRO* A07 Citric Acid Cleaner residue has been developed. The pooled average repeatability of 3 replicates at 6 concentration levels expressed as RSD was 1.3 % while the pooled average intermediate precision (intra-day repeatability in 3 days) of 3 replicates ...

  • Case study - TPH in produced sand for overboard discharge

    Customer uses TD-500D to measure TPH concentrations in produced sand on an offshore oil platform in Malaysia.  The sand contains high levels of crude oils and must be treated on-site prior to dumping it overboard.  The TD-500D was calibrated to Sitelab's TPH calibration kit, product CAL-056.  Methanol solvent was used to extract the samples.  For comparison, samples were also ...


    By Sitelab Corporation

  • Microflow LC offers better sensitivity due to reduced matrix effects!

    What is matrix effect? In my last post, What is Microflow,  I talked about two main parameters,  better sampling efficiency and reduced matrix effect, for microflow LC/MS offering higher sensitivity than its conventional counterpart. Let’s take a close look at the matrix effect. It is a result of ...


    By Waters Corporation

  • Method Scaling in Preparative HPLC: Analytical Method & Preparative Method

    VOC:  “I tried to scale up my analytical HPLC method to prep and it didn’t work.” Andy:  This is one of the most common things we hear from chemists wanting to do preparative chromatography. We also hear the following question pretty often too: VOC:  “I have a good analytical HPLC method, how do I scale it to ...


    By Waters Corporation

  • Characterization of biochar prepared from slow pyrolysis of Jordanian olive oil processing solid waste and adsorption efficiency of Hg2+ ions in aqueous solutions

    Solid waste from Jordanian olive oil processing (OOSW) was used to prepare biochar samples by slow pyrolysis at terminal temperatures of 350, 450, 550 and 630 °C; henceforth known as BC-350, BC-450, BC-550 and BC-630, respectively. These samples were characterized by Fourier transform infrared spectroscopy, scanning electron microscopy and X-ray diffraction, ash content, moisture content and ...


    By IWA Publishing

  • Detailed characterisation of essential oils by flow-modulated GC×GC and Tandem Ionisation mass spectrometry

    Volatile oils of plants, also known as essential oils, have been used for many years for their flavour, fragrance and medicinal properties. However, their extreme complexity and diversity presents analysts with a significant challenge when it comes to quality control. They are generally composed of monoterpenes and sesquiterpenes, as well as their oxygenated derivatives, such as aliphatic ...


    By SepSolve Analytical

  • In Beverly, the Shoe Fits for Bioanalysis!

    This past May, many of the nation’s leading bioanalysts gathered in New England to share ideas and explore the latest advances in mass spectrometry, liquid chromatography, and sample preparation for large molecule quantification. At Waters’ semi-annual bioanalysis workshop, scientists from across the U.S. trained on the latest mass spectrometry instrumentation at our demonstration ...


    By Waters Corporation

  • Leader in sample preparation systems benefits from Axetris MFCs’ high dynamic range - Case Study

    Split ratio flexibility of GC injector increased 30-fold A leading manufacturer of analytical sample preparation systems in gas chromatography (GC) switched to Axetris MFCs - and in doing so, simplified their product range, while offering their customers at least 30 times more flexibility in split ratio. The market-leading dynamic range of Axetris mass flow controllers (MFCs)—with ...


    By Axetris Ag

  • Parallel evaporation after extraction of liquid dairy samples following the Mojonnier method (ISO 1211:2010) – gravimetric fat determination

    Parallel evaporation after extraction of milk samples with the Mojonnier The fat in liquid dairy samples is usually extracted with an organic solvent that is then evaporated to complete dryness prior to gravimetric analysis. In this short note, initial conditions and evaporation settings for the parallel evporation of milk fat dissolved in diethyl ether / light petroleum are presented. ...


    By BÜCHI Labortechnik AG

  • Yes, You Can Pick the Right TLC Plate – Part I

    “I’d like a box of TLC plates, please.” Sounds innocent enough, right? But when you have more than 500 plate options, things get a whole lot trickier. How do you dig through the layers (pun intended) to get the plates you need? TLC plates come in lots of fun forms and sizes—at least we think they’re fun! You can differentiate TLC plates by: Adsorbent material ...


    By iChromatography/Analtech

  • Bacteriological quality of drinking water at point of use and hand hygiene of primary food preparers: implications for household food safety

    Quality of water for consumption and food processing activities is universally accepted as an essential component to ensure food safety at household (HH) level. Along with safe water, hand hygiene is also an important factor for reducing diarrheal illnesses. This was a cross-sectional study conducted in rural and urban HHs to detect hygiene indicators in drinking water samples at point of use ...


    By IWA Publishing

  • VCU Testing for a Major Pipeline Company - Case Study

    Challenge Antea Group was contracted by a major pipeline company to complete a performance test of two marine VCUs and a VOC leak quantification of components during loading of marine vessels. The protocol for both of these tests had been developed by a previous consultant and TCEQ had not yet approved protocol. The client recently purchased the facility and had little information on ...


    By Antea Group - USA

  • Tof-HRMS: Rescuing low-exposure bioanalysis applications from chemical noise

    The drug development process requires pharmacokinetic (PK) analysis to be performed as part of safety and efficacy studies in both preclinical species and human subjects. For high-sensitivity bioanalysis, liquid chromatography (LC) coupled to a triple quadrupole mass spectrometer (LC-MS/MS) is considered the gold standard for quantification. However, for some low-exposure applications, ...


    By Waters Corporation

  • Case study - Canada crude oil sites

    The Canadian Council of Ministers of the Environment requires laboratories to use the CCME’s Petroleum Hydrocarbon (PHC) Method, where GC-FID instrumentation is used to report VPH and EPH hydrocarbon fractions. Sitelab’s popular Extended Diesel Range Organics (EDRO) test typically detects hydrocarbons in the C10 to C36 carbon range, but the UVF will pick up heavier compounds up to ...


    By Sitelab Corporation

  • Metabolic Blurred Lines: Is Biotransformation the next Met ID?

    You are the hunter in a landscape of scientific gatherers, the stealthy SEAL of DMPK, the nimble ninja of ADME. You are a Metabolite ID scientist. Traditionally, Met ID labs have been a fixture of any pharmaceutical company worth its salt. Now, imagine that your proud band of comrades has been phased out, split up, and distributed throughout your organization. Chances are, you don’t need to ...


    By Waters Corporation

  • When Consumables Kits are Greater Than the Sum of their Parts

    ProteinWorks and GlycoWorks kits address more than sample prep challenges One of the most challenging parts of an LC-MS workflow happens before analytical chemists even turn to their instrument: Sample preparation. Get it right, and the analytical run performs as expected. Get it wrong, and the assay has any number of problems, from poor sensitivity to poor reproducibility. The ...


    By Waters Corporation

  • Lead determination in instant noodles

    Wet Digester B-440: Acid digestion and ashing using the Wet Digester B-440 followed by spectroscopic lead determination  Lead determination by ICP-MS using the Wet Digester B-440 for ashing gives reliable results with a recovery rate above 85 % and is in accordance to the FSSAI regulation. For the measured instant noodle samples the lead content was far below the permissible limit. ...


    By BÜCHI Labortechnik AG

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