MtoZ Biolabs Environmental industry Services
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MtoZ Biolabs - dimethyl labeling
"Similar to SILAC technique, Dimethyl labeling is also an isotopic labeling method. However, Dimethyl labeling is a chemical labeling process, and labels lysine or the N-terminal amino acid residues on peptide, instead of labeling proteins. Except for the difference in labeling method, SILAC and Dimethyl labeling technique have comparable sensitivity and accuracy, and are being more and more ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - disulfide bond prediction
To meet specific research needs of our customers, MtoZ Biolabs provides disulfide bond analysis service at both single protein level and proteome level. We have optimized our sample preparation method to reduce the chance of in vitro disulfide bond exchange and maintain the native protein structure to the greatest extent. We have developed a specialized platform, equipped with Q Exactive HF ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - Histone Phosphorylation
MtoZ Biolabs has developed a specialized platform, equipped with Q Exactive HF (Thermo Fisher), Orbitrap Fusion, and Orbitrap Fusion Lumos mass spectrometers, equipped with Nano-LC for histone modification analysis service. To better solve your research problems, we offer an all-inclusive service, including sample preparation, protein purification, digestion, peptide separation, LC-MS/MS ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - Lipidomics Analysis
LC-MS is a powerful tool for discovery lipidomics, as LC-MS usually achieves detection of lipids at ppm level and accurate analysis of lipids side chains through MS2 fragmentation. Whereas, shotgun lipidomics is more widely used for (semi)-quantitation of targeted lipids. MtoZ Biolabs provides both LC-MS and shotgun lipidomics services to meet your specific needs. Service details: ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - antibody c-terminal variation
MtoZ Biolabs uses LC-MS for antibody C-terminal variation analysis, including detection of the proportion of K deletion in the C-terminal end of antibody and other types of truncation on antibody C-terminal. Service details: http://www.mtoz-biolabs.com/pharm-antibody-c-terminal-variation-analysis.html ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - sugar metabolomics
A carbohydrate is a biological molecule consisting of carbon, hydrogen and oxygen atoms, usually with hydrogen to oxygen atom ratio of 2:1. Carbohydrates are important components of organisms, and play multiple roles in regulating various biological activities, such as cell recognition and protein secretion. MtoZ Biolabs has established a platform for analyzing carbohydrates and metabolites in ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - polyphenol metabolomics
MtoZ Biolabs offers targeted polyphenols analysis service using ACQUITY UPLC/TripleQuad5500 (Waters/AB Sciex), which has characteristics of high accuracy, specificity, and sensitivity. We guarantee accurate analysis of polyphenols even in low abundance. With our optimized sample preparation methods, interference from high-abundance dominant metabolites can be hugely reduced, thus further ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - edman degradation
Edman sequencing method analyzes the protein N-terminal sequence in sequential Edman reactions. While mass spectrometry technology has been commonly used for protein analysis, Edman sequencing is still a powerful and irreplaceable method for protein N-terminal sequencing. As a well-established sequencing method, Edman sequencing provides more accurate protein sequence data, compared to MS. MtoZ ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - amino acid sequencing
Edman sequencing method analyzes the protein N-terminal sequence in sequential Edman reactions. While mass spectrometry technology has been commonly used for protein analysis, Edman sequencing is still a powerful and irreplaceable method for protein N-terminal sequencing. As a well-established sequencing method, Edman sequencing provides more accurate protein sequence data, compared to MS. MtoZ ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - disulfide bond analysis
Disulfide bond is essential for protein molecules to maintain the correct advanced structure and maintain protein bioactivity. The distribution of disulfide bonds in antibody drugs is a direct structural characteristic of the drugs. Therefore, confirmation of disulfide bonds plays a very important role in the confirmation process of antibody drug structure. MtoZ Biolabs has developed a ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - targeted metabolomics service
Targeted metabolomics is a study in which defined metabolites in a sample are identified and quantitatively analyzed. Quantitation and semi-quantitation of defined metabolites are undertaken through the use of internal standard compounds. MtoZ Biolabs offers targeted metabolomics analysis service using an LC-MS-based multiple reaction monitoring (MRM) and GC-MS-based single ion monitoring (SIM) ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - Thiols analysis
MtoZ Biolabs offers targeted thiols analysis service using an LC-MS-based multiple reaction monitoring (MRM) and GC-MS-based single ion monitoring (SIM) metabolomics platforms, which have characteristics of high accuracy, specificity, and sensitivity. We guarantee accurate analysis of thiols even in low abundance. With our optimized sample preparation methods, interference from high-abundance ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - quantitative proteomics
"Proteomics is a large-scale study of proteins in a certain organism. Depending on specific research objective, there are many analytical techniques for proteomics study. To better meet our clients’ needs, MtoZ Biolabs is proud to offer 5 quantitative proteomics service, including Label-free, iTRAQ/TMT, SILAC, MRM, and SWATH. We also provide custom proteomics service for specific project. You are ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - post-translational modification
"Post-translational modifications (PTMs) are covalent and usually enzymatic modifications on proteins. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, and so on. These PTMs can cause huge influences on protein structure, distribution, and function, hence, increasing the complexity of proteome to a greater extent. Protein PTMs is generally analyzed by measuring the ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - PTMs analysis
"Post-translational modifications (PTMs) are covalent and usually enzymatic modifications on proteins. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, and so on. These PTMs can cause huge influences on protein structure, distribution, and function, hence, increasing the complexity of proteome to a greater extent. Protein PTMs is generally analyzed by measuring the ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - edman protein sequencing
Edman sequencing method analyzes the protein N-terminal sequence in sequential Edman reactions. While mass spectrometry technology has been commonly used for protein analysis, Edman sequencing is still a powerful and irreplaceable method for protein N-terminal sequencing. As a well-established sequencing method, Edman sequencing provides more accurate protein sequence data, compared to MS. MtoZ ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - Plant Metabolomics Mass Spec
Based on Thermo Q Exactive and AB Q-TOF 5600 mass spectrometry systems, MtoZ Biolabs is proud to offer high-efficient and accurate plant metabolomics analysis service, specific to primary and secondary metabolism analysis. We provide custom service based on your specific research requirements, and assure comprehensive analysis service with the highest accuracy. Service details: ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - antibody gene sequencing
"Although hybridoma cells are immortalized, extensive passage of hybridoma cells may cause mutations on antibody genes, and hybridomas may loss their specificity to produce the correct antibody. Therefore, sequence information of antibody is of extreme importance for stable quality of antibody in large-scale industrial manufacturing. To solve this problem, MtoZ Biolabs has developed a PCR based ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - HCP
Despite of extensive purification steps employed, residual contaminants, as called host cell proteins (HCP), from the biological systems that are used to generate the biologics may still present in the final product. These HCPs, even of low levels, may compromise the safety and efficacy of the biotherapeutical products. MtoZ Biolabs uses 2D DIGE and Western blot technology for HCP analysis. This ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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MtoZ Biolabs - protein full length sequencing
"Full-length sequence information is essential for studying the integrity and correct translation of biopharmaceuticals. In general, protein sequence analysis service provided by MtoZ Biolabs includes three steps: digestion of proteins into smaller peptide fragments; tandem LC-MS/MS analysis of peptides; MS/MS data analysis. Traditional protein sequencing only uses trypsin for digestion, which ...
By MtoZ Biolabs based in MASSACHUSETTS (USA).
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