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MtoZ Biolabs Environmental industry Services

MtoZ Biolabs - MRM proteomics

"Multiple Reaction Monitoring (MRM) is a quantitative method for analyzing targeted proteomics. Based on the sequence information of targeted proteins, MRM selectively analyzes proteins correlating with the targeted peptide signals, eliminating signals from interfering peptides. MRM has the highest accuracy among all proteomics quantitation methods, enabling absolute quantitation of protein with ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - SWATH proteomcis Service

"Sequential Window Acquisition of all Theoretical fragment ions (SWATH) is a brand new mass spectrometry technology co-developed by Dr. Ruedi Aebersold research group (ETH Zürich) and AB SCIEX. SWATH data is an independent acquisition (DIA) technique. Unlike data dependent acquisition technique, which only selects certain MS spectrum for MS/MS detection, SWATH analyzes all MS and MS/MS spectra, ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - edman protein sequencing

Edman sequencing method analyzes the protein N-terminal sequence in sequential Edman reactions. While mass spectrometry technology has been commonly used for protein analysis, Edman sequencing is still a powerful and irreplaceable method for protein N-terminal sequencing. As a well-established sequencing method, Edman sequencing provides more accurate protein sequence data, compared to MS. MtoZ ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - quantitative proteomics

"Proteomics is a large-scale study of proteins in a certain organism. Depending on specific research objective, there are many analytical techniques for proteomics study. To better meet our clients’ needs, MtoZ Biolabs is proud to offer 5 quantitative proteomics service, including Label-free, iTRAQ/TMT, SILAC, MRM, and SWATH. We also provide custom proteomics service for specific project. You are ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - mAB sequencing

"Although hybridoma cells are immortalized, extensive passage of hybridoma cells may cause mutations on antibody genes, and hybridomas may loss their specificity to produce the correct antibody. Therefore, sequence information of antibody is of extreme importance for stable quality of antibody in large-scale industrial manufacturing. To solve this problem, MtoZ Biolabs has developed a PCR based ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - antibody gene sequencing

"Although hybridoma cells are immortalized, extensive passage of hybridoma cells may cause mutations on antibody genes, and hybridomas may loss their specificity to produce the correct antibody. Therefore, sequence information of antibody is of extreme importance for stable quality of antibody in large-scale industrial manufacturing. To solve this problem, MtoZ Biolabs has developed a PCR based ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - dimethyl labeling

"Similar to SILAC technique, Dimethyl labeling is also an isotopic labeling method. However, Dimethyl labeling is a chemical labeling process, and labels lysine or the N-terminal amino acid residues on peptide, instead of labeling proteins. Except for the difference in labeling method, SILAC and Dimethyl labeling technique have comparable sensitivity and accuracy, and are being more and more ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - TMT Service by MtoZ Biolabs

"Isobaric Tag for Relative Absolute Quantitation (iTRAQ) and Tandem Mass Tags (TMT) are two similar quantitative proteomic techniques developed by AB SCIEX and Thermo Fisher, respectively. The most distinctive advantage of these two techniques is that they can label up to 10 different samples and compare the relative proteomic change through LC-MS/MS analysis. Therefore, these techniques are ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - Lipidomics Analysis

LC-MS is a powerful tool for discovery lipidomics, as LC-MS usually achieves detection of lipids at ppm level and accurate analysis of lipids side chains through MS2 fragmentation. Whereas, shotgun lipidomics is more widely used for (semi)-quantitation of targeted lipids. MtoZ Biolabs provides both LC-MS and shotgun lipidomics services to meet your specific needs. Service details: ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - HCP

Despite of extensive purification steps employed, residual contaminants, as called host cell proteins (HCP), from the biological systems that are used to generate the biologics may still present in the final product. These HCPs, even of low levels, may compromise the safety and efficacy of the biotherapeutical products. MtoZ Biolabs uses 2D DIGE and Western blot technology for HCP analysis. This ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - Antibody-Drug Conjugate Analysis

Compared to monoclonal antibodies, the production process of ADCs drugs is more complex, therefore, in order to ensure the safety and effectiveness of the ADC. Comprehensive evaluation of the ADC drug structure, DAR, efficacy and safety is critical before the ADC declaration. MtoZ Biolabs has developed an advanced platform for analyzing ADC, with a variety of high-resolution mass spectrometer ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - Microbial Metabolomics Mass Spec

Microbial metabolomics is a study of the complete set of metabolites within a microorganism. Microorganism is a bunch of small creatures which can not be easily identified by naked eyes, and exist in multiple forms, including bacteria, fungi, and some algea, and have the most diverse metabolic characteristics. Based on Thermo Q Exactive and AB Q-TOF 5600 mass spectrometry systems, MtoZ Biolabs ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - Organic Acids metabolomics

Organic acid refers to organic compound with acidic properties. Organic acids mainly occur in the leaves, roots, and fruits of plants. Except for a few organic acids existing free states, most organic acids can bond with potassium, sodium, calcium, or certain organic acids to form organic salt. MtoZ Biolabs offers targeted organic acids analysis service using GC/MS (Agilent 7890A/5975C), which ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - Carnitine profiling

MtoZ Biolabs uses ACQUITY UPLC/TripleQuad5500 (Waters/AB Sciex) for analyzing carnitine and derivatives. Our service enables highly accurate qualification and quantification analysis of over 355 kinds of carnitines. With our optimized sample preparation methods, interference from high-abundance dominant metabolites can be greatly reduced, thus further increasing detecting sensitivity. Service ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - Carotenoid quantification

MtoZ Biolabs offers carotenoid analysis service using ACQUITY UPLC/TripleQuad5500 (Waters/AB Sciex), which has the characteristics of high accuracy, specificity, and sensitivity. We guarantee accurate analysis of carotenoids even in low abundance. With our optimized sample preparation methods, interference from high-abundance dominant metabolites can be greatly reduced, thus further increasing ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - Fatty Acids GC-MS

Based on GC/MS (7890A/5975C) technology and coupled with fatty acid standards, MtoZ Biolabs can identify and quantitate over 40 kinds of fatty acids in your sample. We guarantee accurate analysis of fatty acids molecules even in low abundance. With our optimized sample preparation methods, interference from high-abundance dominant metabolites can be greatly reduced, thus further increasing ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - Oxysterols quantification

MtoZ Biolabs offers metallomics analysis service using ICP-MS, which has characteristics of high accuracy, specificity, and sensitivity. We guarantee accurate analysis of metals even in low abundance. With our optimized sample preparation methods, interference from high-abundance dominant metabolites can be hugely reduced, thus further increasing detecting sensitivity. Visit ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - Oxysterols profiling

MtoZ Biolabs offers oxysterol analysis service using ACQUITY UPLC/TripleQuad5500 (Waters/AB Sciex), which has characteristics of high accuracy, specificity, and sensitivity. We guarantee accurate analysis of oxysterols even in low abundance. With our optimized sample preparation methods, interference from high-abundance dominant metabolites can be hugely reduced, thus further increasing detecting ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - stable isotope labeling by amino acids in cell culture

"Similar to SILAC technique, Dimethyl labeling is also an isotopic labeling method. However, Dimethyl labeling is a chemical labeling process, and labels lysine or the N-terminal amino acid residues on peptide, instead of labeling proteins. Except for the difference in labeling method, SILAC and Dimethyl labeling technique have comparable sensitivity and accuracy, and are being more and more ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).
MtoZ Biolabs - Acyl CoAs metabolomics

MtoZ Biolabs offers targeted Acyl CoAs analysis service using ACQUITY UPLC/TripleQuad5500 (Waters/AB Sciex), which has characteristics of high accuracy, specificity, and sensitivity. We guarantee accurate analysis of Acyl CoAs even in low abundance. Service details: http://www.mtoz-biolabs.com/acyl-coas.html ...

By MtoZ Biolabs based in MASSACHUSETTS (USA).

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